Mitochondria in the diabetic heart
نویسندگان
چکیده
منابع مشابه
SPOTLIGHT REVIEW Mitochondria in the diabetic heart
Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that derangements i...
متن کاملProtein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes.
Oxidative stress has been implicated in dysfunctional mitochondria in diabetes. Tyrosine nitration of mitochondrial proteins was observed under conditions of oxidative stress. We hypothesize that nitration of mitochondrial proteins is a common mechanism by which oxidative stress causes dysfunctional mitochondria. The putative mechanism of nitration in a diabetic model of oxidative stress and fu...
متن کاملMitochondria and the heart.
Mitochondria are the major site of energy production in the cell. It is not surprising, therefore, that an energy dependant tissue such as heart is affected by mitochondrial dysfunction. In this issue, Holmgren and colleagues report the cardiological findings and clinical course of 17 children with cardiomyopathy identified from a large cohort of children with mitochondrial disease. This is an ...
متن کاملEffect of antihypertensive agents - captopril and nifedipine - on the functional properties of rat heart mitochondria
Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...
متن کاملFunctional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart.
The mitochondrion has been implicated in the development of diabetic cardiomyopathy. Examination of cardiac mitochondria is complicated by the existence of spatially distinct subpopulations including subsarcolemmal (SSM) and interfibrillar (IFM). Dysfunction to cardiac SSM has been reported in murine models of type 2 diabetes mellitus; however, subpopulation-based mitochondrial analyses have no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2010
ISSN: 0008-6363
DOI: 10.1093/cvr/cvq239